We have several production sites which allow us to produce all of our products on regular basis.

 

We have a team of researchers and technicians, that constantly devote themselves in developing new products.

Our product quality is stable with many years of production experience accumulation.

 

Our sales team quotes as per client’s requirements with multilingual speakers of fast response.

We provide fast and safe delivery. We have international logistics services and can deliver services from major China ports and to client’s designated airport or even to door with custom clearing services.

We provide a range of supportive payment methods from T/T to L/C, which caters to clients with different financial situations and be as supportive as we can.

We have customized packing and reliable storage conditions. We deliver to you freshly made high quality materials and our staff are committed in meeting different packaging requirements as well.

 

We provide good after-sales service. If there’s any problem with receiving our products, either material-wise, package-wise or shipment-wise, you can come to our sales service team. We will not hold back in answering any questions that you have.

Best price of 55079-83-9 high purity Acitretin EP powder BP2020

 

CAS NO.:55079-83-9

Molecular formula: C21H26O3

molecular weight: 326.43

EINECS NO.: 259-474-4

 

Acitretin is the free acid form of etretinate useful in the treatment of severe psoriasis and other disorders of keratinization. Although the two compounds have virtually the same efficacy and teratogenic side-effects, acitretin is advantageous for child-bearing women, as its shorter half-life reduces the necessary contraception period from two years to only one month after treatment ceases.

 

Melting point	228-230°C
Boiling point	404.46°C (rough estimate)
density	1.1348 (rough estimate)
Fp	1.4700 (estimate)
storage temp.	2-8°C
form	powder
λmax	352nm(MeOH)(lit.)
Merck	14,112

 

 

 

Acitretin is a second generation retinoid. It is taken orally, and is typically used
for psoriasis. It is a metabolite of etretinate, which was used prior to the introduction of 

acitretin. Etretinate was discontinued because it had a narrow therapeutic index as well as 

a long elimination half-life (t1/2=120 days), making dosing difficult. In contrast, acitretin's half-life is approximately 2 days. Because acitretin can be reverse metabolised into etretinate which has a long half life, women must avoid becoming pregnant for at least 2 years after discontinuing acitretin. Therefore, etretinate is generally not recommended for women of child bearing age with a risk of becoming pregnant. Acitretin is the least toxic systemic treatment for psoriasis. It is an oral retinoid of choice used in the treatment of severe resistant psoriasis. It binds to nuclear receptors that regulate gene transcription. They induce keratinocyte differentiation and reduce epidermal hyperplasia. Acitretin is readily absorbed and widely distributed after oral administration. A therapeutic effect occurs after 2 to 4 weeks or longer. If a patient has received the medication, he/she is advised against giving blood for at least 3 years due to the risk of birth defects.