Progesterone is a strong progesterone, oral or injection are effective, its progesterone activity is 20-30 times of progesterone when subcutaneously injected, oral progesterone is 10-15 times of acetynoprogesterone. The drug also has anti-estrogen effect, but does not antagonize the benign effect of estrogen on lipoprotein, nor does it have obvious androgen effect, most similar to natural progesterone. The drug can increase the consistency of cervical mucus; It can also inhibit the release of luteinizing hormone (LH) of adenohypophysial gland through negative feedback to hypothalamus, so that follicles can not mature and inhibit ovarian ovulation, so it has contraceptive effect. When the drug concentration in blood exceeds 0.1g/L, both LH and estradiol (EChemicalbook2) are inhibited, resulting in blocked ovulation. The antitumor effect of angongprogesterone may be related to its antiestrogen effect. At high doses, the drug can counteract the effect of estrogen on tumor cell growth, and has a direct cytotoxic effect on sensitive cells, but no effect on drug-resistant cells. It can also reduce the level of estrogen in cells by enhancing the activity of E2-deoxyase, and induce 5α -reductase in liver so that androgen can not be transformed into estrogen, so as to produce anti-tumor effect. In addition, the drug can also inhibit the production of LH adrenocorticotropic hormone (ACTH) and other growth factors through negative feedback effect on adenohypophysial gland.