Triethyl orthoacetate is a colorless transparent liquid with a volatile ether odor, B.P. 142℃, n20D 1.3970, relative density 0.8850, insoluble in water, can be miscible with ethanol, ether, toluene, ethyl acetate, carbon tetrachloride and other organic solvents.It is used for the preparation of trans-trisubstituted alkenes and chiral propylene and other alkenes, as well as raw materials for dyestuff and pharmaceutical industry.

• Manufacturing Process

The original three ethyl acetate with the original method of producing three methyl acetate, acetonitrile, toluene and ethanol extraction into salt pan, cooled to - 10 ~ 5 ℃, pass into the measurement of dry hydrogen chloride, maintain temperature into salt - 5 ~ 0 ℃, when after the hydrogen chloride flux, at 0 ℃ for 1 h reaction, and then in 0 ~ 20 ℃ insulation 0.5 h, moved to alcohol XieGuo, salt with the reaction, Keep 20 ~ 25 ℃, temperature, stirring side reaction, about 12 h, intermediates and amino ether hydrochloride precipitation, gradually cooled to 0 ~ 5 ℃, then add precooling of anhydrous ethanol and thymol blue indicator, accelerate the mixing, at the same time slowly to the ammonia to alcoholysis material of neutralization, observe the indicator color changes, until turn from red to yellow no longer red, PChemicalbookH = 3.6, at this time, the ventilation is finished, and then alcoholysis reaction is carried out at 40℃ for about 8-9h. The cooling material is filtered by centrifuge to remove ammonium chloride, and the filtrate is pumped into the neutralization pot. 17% sodium ethanol solution is added, and the pH of the solution is adjusted to be 8 ~ 9. Ethanol was recovered at 75℃, the residual liquid was cooled and filtered to remove acetamide and sodium chloride solids, and then washed with 1% Na2CO3 solution, stratified and oil layer for vacuum distillation. Toluene was first steamed, and then triethyl protoacetate was collected at 88 ~ 98℃/0.07MPa. Reaction equation: CH3CN+C2H5OH[HCl]→CH3C(OCH5)3+NH4Cl